Okay, really strange error that wasn't happening earlier yesterday...then started happening last night and has not resolved.
I can't use QWER or DF to activate anything in game. All abilities and summoner spells have to be manually activated with a mouse to be used.
So far, I've checked the keybindings in the menu (All good,) restarted computer, repatched my client, and updated my keyboard drivers (just in case.)
Anyone have any ideas? I can still type normally using these keys, so it is not like the keys just don't function. Hoping someone can provide an answer.