First off i have 2 questions

One will i be able to play LoL forma flash drive
Two will there be a difference in gameplay between a usb2.0 port and a usb3.0 port

bump would very much like to know the second question

no. and no.

yes u can play.. but it'll have huge lags since the client and in-game specks are being imported as u play...

Bump anyone know the answer to the second ques?

Theoretically yes, but it's still not going to be fast enough.

but would it be faster if i use a usb 3.0 port

I've done this with LoL and other games and I have NEVER noticed a difference.

Maybe your initial load time is a little slower, but that's it.

i never had any lag problems when running LoL from a flash drive

you'd probalby need a solid state flash drive (it's a drive that runs nearly at the speed of the memory of your computer)