Since you are not adverse to creatures, Riot, could we possibly see a champion based on H.P. Lovecraft's works? I don't mean some stupid C'thulhu copy - Shoggoths, Flying Polyps, Shub-****urath, Yog Sothoth...all have common themes of discord, asymmetry, chaos, incomprehensibility, and the unknown.
What I'm asking is if you'll make a champion that looks, feels, handles, and plays just plain wrong. A champion that evokes feelings of paranoia and fear when looked upon. Something with insanity in its skillset - literally. I would love that.