What is the best rune set for every character ??
(mark,glyph.seal and quintessence runes )

thanks~

Overall I'd go

Blue - CD per Level (almost every hero this comes out being useful, though some heroes might not recieve as much benefit as others)
Yellow - Dodge/Health (Good for all)
Red - Varies. Crit Damage for most carries. Armor/Magic Penetration. MR/Armor (in cases you won't invest on one item to give any)
Quint - Varies as well. Health Runes are very good for all characters in general. More specific ones can be gained depending on the character. CD reduction per level quint are really good here too in general for most characters as well.

its best to find synergies. stacking any one thing isn't usually a best approach, with the exception of cooldown reduction

10% cooldown reduction with 100 dps through abilities= 111dps.

20% cooldown reduction with 100 dps through abilities = 125dps

40% cooldown reduction with 100 dps through abilities = 166dps

however attack speed works the opposite way, as does crit chance, damage, crit damage, etc... Those items are usually best used as a blend. 10% crit chance + 10% attack speed is better than 20% of either.

armor/magic pen can be a little weird, as it knocks flat amounts off of enemy armor. oddly enough, this matters most with lightly armored opponents. 20 armor pen will increase your dps by 20% vs a character with only 20 armor, but only 5% vs someone with 100 armor.

personally, I find mana regen runes to be essential in almost every game. they're my must-have, regardless of me building dps, defense, cooldown, or whatever.

hit point/mana runes tend to be cool up front (at least if you're getting ganked a lot), but barely matter past the first 10 minutes, as by then the HP bonus is trivial in relation to incoming DPS.

These runes are consistently stacked by a lot of high-end players:

Red: Armor Penetration or Magic Penetration, depending on the champion. Critical Chance isn't bad, either.

Yellow: Dodge, scaling Health, and scaling Armor.

Blue: Scaling Magic Resist and scaling Cooldown.

Purple: Armor Penetration/Magic Penetration (again, champion-dependent) and flat Health.

ahhh ok thanks guys~ .....I think ill go
yellow : dodge
red: crit damage or ma/ a penetration
blue : cooldown
purple : health

thanks again~

why would you want scaling runes?

by the time you are level 18, the effects of your runes are pretty small. vastly outweighed by the items you are carrying.

on the other hand, at level 1 you have no items. the non-scaling runes offer a huge advantage to low level stats. from what i can tell, the best strategy would be to rely on the non-scaling runes for early game stats, and items for late game stats.

ahh!!! those crit damage runes aren't useful to you untill your crit reate hits 60% or so... at least compared to crit chance runes.

also, scaling runes are useful with mana regen because they pass the benefit of the flat ones by L5. The cooldown reduction ones are more of a toss-up. some (i forget which ones) are really ****py and even finish lower than the flat ones start!