After about a year of Karthus as a main I can tell you he certainly can be powerful and fun, but is equally vulnerable in the same respect. For starters, there are so many more mid counters to Karthus than I can count on both hands. He is terribly squishy and is almost guaranteed to lose a 1v1 pre-six. His damage simply cannot compete at lower levels and he can be shut down extremely easily. Thus, his only option is to sit back and farm, snagging whatever he can with R until the teamfights start.
My suggestion, be extremely aggressive early before the jungle has a chance to get around to mid. You'll likely win the 1v1 and force him to play passively and extra cautious. Once forced into that mindset he will undoubtedly have a more difficult time farming. I shouldn't even have to say this, but run from side to side and try to judge where he'll Q next. Never run away in a straight line. His Q's are terribly easy to dodge, really.
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