Anyone know if the active passive on muramana works on her ult per sphere?
I just tried it and couldnt really tell. Had to go to work so couldnt test more.

http://leagueoflegends.wikia.com/wiki/Muramana

Last line above the 'Trivia' section says it does, I'm willing to believe it. I don't suggest building one on her though.

very good question but yes, still not worth building on her if it does work

That depends on what else you're building. Muramana will provide you the highest single target burst with your ult available.

And then the rest of your kit will do basically nothing while your ult is on cooldown, largely invalidating the choice of playing Syndra at all.

Because you're never going to autoattack with 600 range.

Don't tell me what my raison d'etre is. If I want to play a mage with autoattacks, I will. It's not like having an infinite mana pool is at all detrimental to playing Syndra, and it's also not like Archangel's/Seraph's will increase my damage per spell by a comparable amount.

So you have a little bit less AP than you would have otherwise. In exchange, you're a lot more flexible, which is one of the purposes of playing Syndra. If you never intended to use a ToG item, well that's your choice, but don't pretend that there aren't advantages to doing so.

Each sphere of her ultimate will trigger Muramana.

I usually buy Tear and upgrade it into Muramana as my second or third item.

http://leagueoflegends.wikia.com/wiki/Syndra/Strategy

Her ability to insta-kill someone with one skill more than makes up for it being largely useless while her ultimate is on cooldown. It's not like the rest of her abilities deal low damage...

Grab a lichbane if you are afraid to autoattack. Now you WANT to do it.