What runes should I be using on him?
What route should I take?
What item should i buy first? Then what should i be building?

Links, posts anything would be VERY helpful!

Masteries: 21/0/9
Runes: Attack Speed Marks and Glyphs, Flat Armor Seals, with Armor Pen Quints.
Starting Item: Vampiric Scepter, QEQW then R > Q > W > E

Route: You can either do the route that Stonewall demonstrates in his video or you can use the one Phreak used in the champion spotlight.

Stonewall's: http://www.youtube.com/watch?v=BHEIBWKRUgQ

Phreak's Spotlight: http://www.youtube.com/watch?v=VmXEnxyVcs0