In Nugg's defense (because somebody has to), I think he meant to say simpler skill shots. It would mean mid-fight you can just hit the key, reducing the two-tap activation to a one-tap activation. It's not a bad idea.
Maybe have an option to toggle this on and off for skillshots in general.
I'd also like to see a double-tap system implemented for buffs, where rather than clicking on yourself to buff/heal yourself, if you press the hotkey twice, it automatically works on you. This would be particularly good for Kayle's revamped ulti, for example (even though I'm of the opinion that it needs to be changed, it makes a good example)