So I was trying to search for another thread that had the same issues, saw some, but with no answers. I'm running on Vista, just installed today, everything installed just fine, but I got online to join a practice game with a friend, received the unknown error that was previously stated, (which could have something to do with it) but when the game started, after choosing my hero, I froze for a good 30 seconds, then I was the last to load, then it froze again for about 30 seconds, then my friend said I disconnected. I had similar issues with Ventrilo when I first installed it, but I had just disable Direct Input and it works fine. I couldn't find anything in the settings for LoL that would cause the mass freezing and ultimately led to my DC.
Anyone else having this issue?