Depends entirely on the enemy team's composition. If you're up against Champions who tend to get high HP like Vladimir, Mundo or Volibear, it's a good choice. Otherwise, it's extremely expensive and should be a late-game item at best.

You'll more often get better mileage out of a Wit's End for general combat purposes.

I understand why you would want to do this, but please, just don't. It's not that it's a bad idea, but MBR is just way overpriced for what it ultimately gives. Right now MBR is ONLY for countering the guy who has Atmogs + Frozen Mallet and thinks he doesn't need magic res.

Buff the proc on the Dominion razor, please. 2% is so low... Wit's End will basically ALWAYS do more damage, for less cost.

Well you could always join Trinity Force anonymous Phreak, They help you with Tons of Therapy

Shyvana says 8% max HP AoEs on a short cooldown are strong.

But Shyvana is a special case - all on-hit abilities are extra nasty on her.

This, Vayne's are already winning at this point, and it's just icing to the cake.. Her larger damage would be silver bolts, so any AS item higher would be better. Def not a rush, she farms well anyhow.

How do you feel it works on Twitch

I find that if I build MBR and BT it makes gives me that AS, and AD. Twitches Ult adds AD so you can really put it into somebody and with the way your Q works and the way your ult works it really helps against those heavy tanky dps teams and seems to win me and my team a bunch of games.

Essentially it's my standard build when I know they're going to have some 3k+ bruisers or tanks

So is a Teemo building a bloodrazor/malady just a worse version of kogmaw?

It's also great on Shaco because your clone will also proc it, essentially doubling it's power. It's also great for melting baron.

I might also build it on someone like Yi or Tryn if I am reasonably sure the enemy team is going to stack armor over MR. (A big reason it's great on WW, a lot of players tend to mistakenly itemize armor against a WW who is doing well.)

MBR/Malady teemo might be the single hardest thing in the game to properly itemize against. This is why a fed teemo can become so unstoppable. IMO, Madreds/Malady might have the *real* best item synergy in the game. Atmogs can suck it.

MBR > Volibear