Edit - Summoner Name / Account name Negastoat. Posting here with my specifics.
Abit KN9 SLI motherboard
AMD Athlon 64 x2 4400+ processor (revision 23 bios)
Nvidia 8800 GTS card using 306.02 (August release) driver.
4 gigs of ram
Win XP service pack 3 updated to current.
Previous to Syndra patch - no game issues at any stage, all owned champs usable.
Post Syndra patch (to this current posting) - Diana causes a bugsplat error anytime after 12 minutes of the game, when a Q is used. Will only Bugsplat crash once, but happens every game. All other champs usable.
Game was uninstalled, all folders / files removed, registry cleaner used, then game was reinstalled (after Syndra patch). Problem persists, Repair tool is useless as a remedy.
Above computer is able to run Skyrim flawlessly on maximum settings (less shadows set to Medium), and Guildwars 2 at 36 FPS and 24-26 FPS in high intensity fights. No issues with any other demanding games.