Well, it really depends on what champion you're playing. If you're playing annie, let someone more tankier initiate and you can drop your tibbers/incinerate in the middle, hitting every really. But lets say you're playing someone more focus heavy like Lee Sin. Quote "Don't be Julias ****ing Caesar, Initiate!" Focus someone, your team will most likely follow you to whoever you hit, because you initiated the fight, if you're not the one who initiated just follow the person who did, that's what works.