Originally Posted by Rylentlar
Aside from having armor runes on a jungler I have not seen much use for getting specific rune pages. I reorganize mine every once in a while and I cant' seem to feel a difference in gameplay.
Where do runes normally help and what are the benefits of making pages specific to champions?
Runes usually help early-game, when harassing is key to bullying opponents out of lane and claiming free minion farm, and occasionally late-game if you have per level runes (these are usually used to make up for a lack of item purchases late-game - i.e. beefing yourself up with magic resist per level runes if you don't usually buy a lot of magic resist on your assassin or nuker characters).
While all champions benefit from having specific rune pages, some do so more than others. Bruisers like Jax, Darius, and Lee Sin can usually get away with similar rune pages (armor, attack damage, magic resist per level) that allow them to trade well early-game and late-game give them a bit more beef against nukers that can easily burst them before they get damage out.
By contrast, Akali is a champion who benefits IMMENSELY from her own rune page - so much so that some players will swear that the only way to play Akali is to spend 100+ games farming up the perfect rune page for her. This is mainly due to her passive, which requires she have enough starting AD and AP to activate, having AP and AD runes benefit her immensely early-game. Not to mention that she usually doesn't build any AD items except her Hextech Gunblade (which is expensive and denies her the AD half of her passive for the early-game), so if you want both her AP and AD passive up you're best off just making a rune page for her. She is worth it (very strong top lane and ganker) but it takes time.