This thread isn't about gender-swap skins, though considering how many of those exist I imagine the community has thought about this a lot.
My question to you is this: Which characters do you think would be more unique/interesting if their *** was changed from Male to Female or vice versa. Nothing else in the lore is changed, unless it has to to meet the new *** (i.e. if part of the lore was a heterosexual marriage to a woman, the ***-swap would make that to a man to keep everything the same.)
May as well start.
Gragas is already an interesting champion, but part of his design plays into the stereotypical fat man heavy drinker. What if Gragas were a woman? Tall and still perhaps broadshouldered/strong from the magical booze she's slugging, but def a female. It doesn't matter really if she stays fat or not, the character I think becomes more striking just from that a lone.
Going the other way we have Janna. Quite a few depictions of air casters use them as females. Not only would Janna as a male give another male support (wee!) but if you kept the other aspects of the character true, we'd have a pretty unique looking male character. Especially with the revealing clothes (oh my!)