What do I mean by this? Well, I've been getting into Fire Emblem: Awakening recently, and the game rules. Pretty good story, great gameplay (if you can handle the difficulty), etc.
Makes me think: What would it be like if someone were to write a LoL fanfic that's inspired by the Fire Emblem series? Basically, Champions fighting in escalating mass conflicts that eventually threaten the safety of the entire world, but said battles are not contained on the Fields of Justice. More open-war kind of stuff.
I dunno if anyone plans to do this, but it's a thought. In the meantime, if there were a LoL-Fire Emblem cross made, I'd have Leona and Lux as my lords.
Leona would obviously be a defense-type Lord (standard Lord growths, but only par Luck), while Lux would be a caster Lord (ala Micaiah from FE10).