Originally Posted by dustofoblivion
I don't think it's already possible, but if it is then I apologize.
I have always used keys to move (for ex.: w,s,a,d) and I find it a bit annoying to always have to use the mouse to make your Champion move.
I see you have never played Runescape. Yeah! Good job. You would have to get used to the mouse. It won't take long to learn how to use it well. You'll develop hand-eye coordination as well. LOL has 3-D elements to it. It'll cripple you if you use wsad to move.
Edit: If you had not found out yet. You can right click on the minimap to make your champion move all the way over there. I think you play with your camera locked all the time, and click everywhere. Try unlocking your camera, move it someone far, and click to move. You'll get there with the automated pathfinding. If you already know this, don't hate on me