After taking a little bit of time, I've come up with a very fun build on Miss Fortune that looks like it will wreck a team pretty hard, and I figured I would share it and see what my fellow PBE users though. I don't even mind if ya use it for yourself (or I wouldn't be posting it!)
The full build goes as follows:
Furor Berzerker's Greaves
Blade of the Ruined King
The above build will grant you up to over 400 AD, ~1.9 AS with Attack Speed runes and Impure Shots active, up to ~4x% Life Steal, and up to 25% armor reduction on a full team. You hit R and reduce an enemy team significantly, and then you start auto-attacking. Each auto will deal ~200 damage and 4% of a target's max health as physical damage to the champion standing next to your target. Oh, and did I forget to mention, each auto-attack is boosting your Movement Speed by 12%? So, if you keep Strut active, you'll have like 500+ MS!
Of course, the obvious flaw to this build is that there's no Crit. The goal is not to blow up one target at a time, but to annihilate an entire team all at once, mostly by getting a Penta-Kill by the Triples (think about it for a second, and that makes perfect sense).
Let me know what you guys think about my AoE Queen build! If you think another item would be better than what I have listed, then please let me know! Just keep in mind, the main goal is not to blast out one target, but to take down an entire team at once.