Sometimes while playing I will get massive lag spikes, (Presumably on riot's end, as I can still give commands and my UI still responds, I just can't move or cast). If I leave game once or twice and reconnect then all of my problems go away. I've tried re installing League, and I've tried deleting Pando. Neither seem to be working. Please help.

same thing has been happening to me and its been very annoying.

Same here, this problem comes back every few patches, all riot ever says is its something on our end and they just ignore the issue and move on. :/