Ryze is of honorable note against any champion that charges at you. Bear with me here, if you max your E first as Ryze, every bounce reduces an enemies mr by 24. You cast it as he jumps to you, it bounces 5 times, 2 times off of Ryze. Fizz is now at -72 mr, probably putting him negative, and you just did like 400 damage, and if you ult before hand, you probably just healed a ton as well.
There used to be a glitch with Ryze's E, if Poppy, Lee, or anyone tried to charge him, there is a point where the 2 of them are at the same location, and the Spell Flux would bounce infinetly. I'm pretty sure it was fixed, but it is still a very strong ability against people that charge at you, just because of the bouncing from you to them mechanic.