Having a button on gaming mouse that allows to make a ryze combo. 1 button=e+w+q combo

No, more like nerdy

ewq? I think you have the combo wrong.

skills.

No.

If that's the combo you're using, you're gimping yourself.

No, but it's not really needed when playing Ryze.
Most people just use their face.

It is, a lot of people have been saying no so far but Riot does consider that cheating. I remember a red post on the topic before that said that one button press had to coincide with one action. Push q, q happens. They stated that pushing one button and having multiple actions occur is considered cheating and could net you a ban.

Also Ryze QWEQ or QEWQ if they aren't running away