Big Daddy Nasus don't give a ****, just farm top lane all day. Once you've got at least 10 minions under your Q, you should easily be able to overwhelm your opponent rapidly. Once you're level 6, you almost smile when they gank, because that doubles the AD build up from your ultimate. Once you're carrying Trinity Force, you have become the juggernaut of death and destruction, pointing at the next dead man and watching them freeze in place as your team descends upon them, thankful for their next meal.
Either that or Brand. Just set everything on fire, and you're bound to win eventually.