Originally Posted by Cenerae
Vayne's Silver Bolts can only be applied to one target at a time. It doesn't work, you'll only get the bolts applying to your primary target.
Depending on the enemy team, and assuming the game goes that long, I'll consider picking up runaan's, primarily for the attack speed since with my setup it'll put me at 2 attacks per second. However, I'm more likely to slot a last whisper. But yes, Silver bolts is strictly a single target. Vayne would be insanely popular if a runaan's allowed silver bolt procs on 3 targets at a time, or at least I would think it would make up for her weak early game.