As a player who uses a left-handed mouse, the support is appreciated. I have QWER rebound as op and summoner spells as kl with backslash as the scoreboard. Works pretty well. I need to get a keyboard with printed keys because while blank keys are good for touch typing, they aren't exactly great for gaming. Right now I only have inventory 1-4 bound as 90-=, if I had printed keys I'd be able to bind all 6. (I tried binding 6 and it's out of the range of my small hands.) Thankfully LoL doesn't have as many active items as Dota 2 so I can kind of get away with it.
Anyway, I just wanted to say thanks for actually bothering to support players like me being able to bind everything however we want.