Hello,
as said, I am a left-handed person. My mouse is the Razor DeathAdder Left-Handed Edition.
Now I have a problem. My mouse is on the left side of the keyboard, but I use "left click"" and "right click" like a right-handed person. So left click and right click were interchanged in LoL. Thus I downloaded the input.ini data by Riot to solve the problem. And it worked perfectly, except one fact: I can not change the keybindings when I'm in a game. No matter what I wanted to change, my left Mouse click is now the key that I wanted to change.
For example: I want to change my Q to smartcast Q, so I just have to press Q to cast spells immediately. But after I changed my settings, I smartcast my Q spell now with my left click.
Help?

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Using the input.ini settings you had ealier go into C:\Riot Games\League of Legends\Config and add the lines:
[GameEvents]
evtSmartCastSpell4=[r]
evtSmartCastSpell3=[e]
evtSmartCastSpell2=[w]
evtSmartCastSpell1=[q]

my input.ini already looks like this and nothing changed:

[GameEvents]
evtPlayerSelectClick = [Button 2]
evtPlayerMoveClick = [Button 1]
evtPlayerAttackMoveClick = [Shift] [Button 1]
evtPetMoveClick = [Alt] [Button 1]
evtPetReturn = [Alt] [Button 2]
[HUDEvents]
evtOnUIMouse1 = [Button 2]
evtOnUIMouse2 = [Button 1]
evtOnUIMouse3 = [Button 3]
evntHudMoveableSelect = [Button 2]
evtOrbitCamera = [Ctrl][Button 2]
evtSmartCastItem6=[6]
evtSmartCastItem5=[5]
evtSmartCastItem4=[4]
evtSmartCastItem3=[3]
evtSmartCastItem2=[2]
evtSmartCastItem1=[1]
evtUseItem6=[<Unbound>]
evtUseItem5=[<Unbound>]
evtUseItem4=[<Unbound>]
evtUseItem3=[<Unbound>]
evtUseItem2=[<Unbound>]
evtUseItem1=[<Unbound>]
evtSmartCastAvatarSpell2=[f]
evtSmartCastAvatarSpell1=[d]
evtSmartCastSpell4=[r]
evtSmartCastSpell3=[e]
evtSmartCastSpell2=[w]
evtSmartCastSpell1=[q]
evtCastAvatarSpell2=[<Unbound>]
evtCastAvatarSpell1=[<Unbound>]
evtCastSpell4=[<Unbound>]
evtCastSpell3=[<Unbound>]
evtCastSpell2=[<Unbound>]
evtCastSpell1=[<Unbound>]

Bump!