Originally Posted by Yasako
On the Garen and Katarina count: Eh, a little iffy on that one. Romantic tension is one thing, romantic relationship is another.
Varus likely didn't know some Noxians existed before he joined the League. He probably doesn't have enmity towards anyone in particular, just all-out rage.
Fair enough with Garen and Kat, but for Varus, "He left [Ionia], seeking the blood of all Noxians involved with the invasion, a grisly task that eventually led him to the invasion's most infamous perpetrators in the League of Legends. "
He specifically came to the League of Legends just to hunt down the Noxus Champions that were involved with the Ionian invasion. Riven and Katarina were both there in Ionia in the invasion. Katarina got some of her first bits of action there (provided the old lore is still somewhat valid) and Riven had her command blown up by Singed. If he is going after the Champs from the rematch that would add Miss Fortune, Morgana, Singed, Vladimir, and Sion to the list with the possibility of the Reserves: Kog'Maw, LeBlanc, Rammus, and Shaco. If nothing else Katarina, Riven, and Warwick (here was there too as mentioned in JoJ 12) are on his list with Singed being another probable even though he is from Zaun (him and Warwick teamed up against Soraka during the fall of Ionia to Noxian forces).