Nothing is happening Click the icon to open it up shows the Logo and then disappears, the patcher isn't showing up or anything. Did a System Restore, Re-installed it, even did the Delete the Rads, and replacing it ETC, ETC. Nothing worked any suggestions?

Try downloading AVG and deleting your old antivirus, AVG has an interactive firewall and its asks you whether to allow it or not, tried all those things you did and this was my only solution. Its annoying because I had a payed for subscription of trend micro ;L

I have AVG, still nothing.

Restore defaults and change it to interactive, and wait for it to ask you

nope, Even disabled firewall all together, are we even on the same topic of problems? It doesn't even try and find a connection, it just doesn't open the program at all.

This same problem is happening to me. I install everything all the way up to when im ready to hit PLAY and when I hit PLAY nothing happens. The client does not start.

Most likely files from the older install were still remaining when you reinstalled, can you try to reinstall one more time following this guide:
https://support.leagueoflegends.com/...gue-of-Legends

Just did the same thing for me, wasn't an install issue...plz halp.