I love the two hero combos that produce early kills and set players behind a couple levels. I've seen a lot of these with a Blitz in the forward most grass with someone with a decent early nuke. When Blitz gets grab and punch... he can damn near gank an unwary player alone. I prefer nuke with it over stun because early stuns probably won't be long enough to get enough charged punches for the kill.
On top of the early kills, this creates an amazing amount of pressure on the player(s) laning against it, esp. if the Blitz and other play aggressively. It usually sketches me out, esp. with an carry like Ashe. There's just not a lot you can do except flash.. then you're screwed the second time they do it.