Originally Posted by DonkeyBalls
Why get it on any character over Infinity Edge or Mandred's Bloodrazor? Do some champions synergize better with it than others? Who would prefer it and why?
If you do decide to choose Bloodthirster over the other uber weapons, should it be rushed? It is tempting to do so since the Vampiric Scepter start is a common one. Is there a hurry to build up those stacks or are you better off waiting until you have a few smaller items before investing in one so expensive and undependable?
It provides the single largest attack damage boost of any item in the game, as well as the single largest Lifesteal of any item in the game. The former is very good on champions that have abilities that scale off of base damage (Katarina's Bouncing Blade and Death Lotus, Pantheon's Spear and Heartstabber, Corki's Gatling Gun, Shaco's Shiv, Tryndamere's Spin, Ashe's Volley, Gangplank's Parrrley, though those last four benefit more from Infinity Edge as they benefit greatly from crit chance/damage). For Kat especially, Bloodthirsters are vital. However, it's generally better to acquire a couple of BF Swords before upgrading to Bloodthirsters. Madred's is generally a lesser case on most DPS heroes, and should really only be built if your enemies are stacking a lot of HP (or if you are facing down Cho/Mundo). Last Whisper generally gives a lot more cost effective damage output for a +40% attack speed item.
Once you have a Bloodthirster, it's not too hard to build up stacks. Your damage is generally high enough to clean up waves of minions, particularly if you're using a splash ability like KI'd Bouncing Blade, Heartstabber, or Gatling.