It's cheaper to combine 5 of a lower tier than to just buy one.
Combining 5x T1 damage runes (some of the cheapest runes you can get) = 75 IP.
Buying 1x T2 damage rune = 80 IP
Combining 5x T2 damage runes(bought for 80) = 400 IP
Buying 1x T3 damage rune = 405 IP
Combining 1x T3 rune from 25 T1 runes = 375 IP
The only problem is the rune you get from combining is random, so it's not really worth doing unless you have some empty slots and don't really care what runes go into them.
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