Originally Posted by Cyda

There's a common misconception that you must use 9 of a specific rune. You could always use a mix!

My tank page consists of 30 Armor / 17 Magic Resist all flat, simply because I prefer having a really strong early game which is where runes really shine. Though I suppose scaling glyphs will influence late game more than flat. Keep in mind, Nasus has a pretty beefy base and growing HP stat AND a health bonus ultimate on top of that, so defense will benefit more than health from runes. Specially since you need to be constantly in and out of the fray to last hit.

Quints/Seals are Armor
Glyphs are Magic Resist
Marks are a mix of Armor and Magic Resist

If you are shooting for cooldown to get to 40% though, chances are you will include a Frozen Heart in the mix as it provides hefty armor. In this case I would throw in full Magic Resist Marks and possibly even Quints.

Your best bet is to make various tank pages revolving around the defenses I mentioned. If you are playing ranked, you can determine what will be the best route depending on what the enemy team is going. There's not much sense to stack huge armor if your opponents are Malzahar, Anivia, Annie, Vlad, Veigar.

Originally Posted by Xtiangames

Armor Pen, because even if you are going tank and even if you're hoping for long games, nothing will make your Q hit harder (and therefore frighten people into attacking you instead of your carry) than a stupidly big Q hit.

Originally Posted by BiggieSmallsssss

hmm, yes, armor penetratin would be nice, but wouldn't a maxed armor penetration marks of about 10 only be equivalent to doing an extra 10 damage? (I'm not sure about the armor penetration math but that was my guess of how it worked) That would only be equivalent to about 3 or 4 extra q strikes. And late game I can pretty much one hit most of the smaller minion creeps. (My normal elo isn't that high so oppoenents often allow me to be constantly q striking all throughout the game)