right now im using
red = magic pen
yellow = health regen /lvl
blue = ap /lvl
Q's = ap /lvl


i dont know if u wana spend the 4k on ap /lvl yellow runes.

should i get base hitpoits?
hp/lvl
ap /lvl
or what?

I would worry more about getting rid of the armor penetration marks. For the glyphs i would go for mana regen/level or dodge or hp/level

If you're jungling, you want:

Red - Mag Pen
Yellow - Dodge or Armor
Blue - AP18 or CDR18

If you're not jungling:

Red - Mag Pen
Yellow - Mana regen or Dodge or HP18
Blue - AP18 or CDR18

You have armor penetration runes for fiddle? I'll be the first to bite on a troll post. Look at my profile for the optimal runes.

Lane Fiddle

Red: Magic Pen
Yellow: HP/Level
Blue: CD Reduction
Quints: +1Gold/10Sec

My Jungle Fiddle page

Red: Same
Yellow: Sam
Blue: Flat AP
Quints: +2% Exp

i don't use Magic Pen since it doesn't help in getting -res

Hp/Lv does seem the way to go for yellow i have a set of dodge runes but they just dont work very well.

20 from mask
20 from boots
10 (16) from passive
20 from scepter aura

that is -70 without masteries or runes and most people don't have that much res till way late game and your carry should be able to pick them off now. i have the mask and boots and my catalyst before 15 min usually have finished my rod on many occasions.

now i use the armor pen so at lvl 1-4 when im harassing the people in my lane with dark wind, my auto attack actually hurts. gotten tons of first bloods very fast because of this.