I don't blame you for looking at Manamune, it certainly seems like a good choice, and it's not bad...except for the fact that runes/masteries don't synergize with it.
Lets put it this way: You want "enough" mana regen such that you can get through fights and sustain. You can achieve that using exclusively Runes and Masteries.
Manamune provides Mana and AD...which is good, but if you got your mana from Manamune, then you would want to convert your Runes and Masteries to something else. Simply put there isn't anything truly worthwhile to put your Yellows/Blues and 9 mastery points into.
What you can get out of that doesn't outweigh what an item slot dedicated to damage, or CDR could benefit for you.