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Or you could just keep the answer simple and just do what the pros do. Look up featured guides on SoloMid ... just about all the ad carries go full ad runes. The numbers are good to know just in case you want to change your game and make it unique. I prefer following the people the have proven their success.
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thats not always true
these "proven" players have also honed their skills in game and rely completly on their skill coupled with the champ they are using to maximize its efffectivness hence diffrent builds that are viable, skill orders and even purchase plans: they are designed to be maximized for the game they are in and are not simply a "standard" that can be used or followed.
most proven players have their own play style, and usually their settings and rune/masterys are desgined to fit how they play.
I suggest finding a rune/mastery setup even build orders that you are comfortable playing and play successfully.
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and I play Zilean for a Mid and I get **** for having low AP because I use Magic Pen Runes?
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most champs have relitivly low magic resitance {30} and this dosent scale
a few champs have scaling magic resitance starting at {30} - {51} at level 18
since all your abilites are scaling based on AP, its most effective to use Magic Pen marks, Flat ap quins, scaling AP glyphs, and mana regen seals.
once you get sorc shoes you have more then enough magic pen to be an negate most of there restistance {which is why the additional magic pen becomes ineffective and more ap is better}