While I personally haven't had any really vicious reactions from people when they find out I'm a woman, I have had guys remove me from their friends list or start avoiding me after finding out through a conversation or inviting me to their vent.
These were people I'd been playing with for a couple months, so that type of reaction was, to me, more insulting than verbal harassment. I've done my share of lurking, my skin is pretty thick, but really guys? I'd like to see that sort of childish reaction disappear forever.
But hey, I've found new respect for Shaella in this thread, and also her stuff on Crocout with her fling RenBot is pretty good too.
And finally, I really REALLY hope Iron isn't talking about GEM, she of tournament prize withholding, 'omg guys stop harassing me just because I'm a girl, hear that, I'm a girl, broke up with my boyfriend to play LoL, hey look at me' infamy.
EDIT: I don't remember who said birthday suit Malzahar before, but yes please, I'd be all over that. I don't play him but my boyfriend does, and I would buy him that skin just to watch him play it.