You know - I love that you reference makoto for this. She's one of my fav's ^_^
I could definitely see a champ who has 3 abilities that are all auto-attack cancel moves, each with a mild effect. Obviously you could chain them together, and maybe it would give you some special proc if you use them in a certain order. Then you could activate her ult which powers you up and gives you really reduced cd's on your normal 3 abilities so you can basically endless combo them, continually re-procing your added effects, but maybe for only 6 seconds. 100% single target champion designed not to assassinate, but to take out bruisers by having lower cd's and good resilience, and the potential in a prolonged engagement to utilize the duration of the ult to unload a !@#$storm of attacks?
Basically a champ who doesn't need attack speed, because it's all cd's on abilities that reset auto attacks.