Thanks people, ill look into all of these and see what i like.

(that doesnt mean stop posting other options though :P )

I have a Steel Series Kana and it works pretty good and it was only like 55$ which is a lot cheaper then most Razer stuff

I play ADC, and only play with premades, so I'm ADC 98% of the time. I really don't need to deal with item actives (aside from the wards I buy, and even then, I prefer not having it smartcasted).

I don't run push to talk for anything. I play in quiet areas and can adjust the sensitivity well enough to not annoy others. Doesn't having it on 1 strain your hand (if you talk a lot)? You could move it to 2 or 5 or 8 for a more comfortable hand position.

I can type "re" without moving my left hand (changed keybind for "enter" and "shift + enter").

I don't mind moving my right hand for the other ones. I can see how that would be a convenience though. Again, 98% of the time, I'm in a premade on Skype. No need to type really.

Now, I'm not saying that a mouse with extra buttons isn't cool, but buying a Naga (or anything comparable) just to play LoL is a waste of money, in my opinion. If I were the OP, I would go for a Razer Deathadder or similar.

I use Razer Naga, but gaming mice really shine in MMO's and, to an extent, FPS games. For League, the buttons on the side of the mouse make it easier to use items rather than having you use my left hand and make it leave the QWER to press 6, but then again, it's not that big an issue.

Genius. Never thought about doing this, but amazing way to use the mouse.
Also, I use my Razer Naga for everything.
1-6 Q W E R D F
7-12 (1 2 3 4 5 6)
I use the arrow keys and stay unlocked, sometimes I have my left hand off the arrow keys and have pinky hovering over tab and use space at times.
I can't play using standard too weird xP

Oh and, the deathadder is amazing, i'd say its the most popular gaming mouse. I owned it before winning the naga in a contest the best feel in my hand ever. The mouse is incredible i'd recommend it any day of the week

I like the Naga but i think the Naga hex is perfect for LoL, may wanna check it out...

It looks pretty cool, but doesnt it have Way too many buttons for LoL ?

I use a kinzu its pretty good but now I want to get the sensei soooo bad (1.6 player)

pfft....lol noobs.Go use logitech mx518 or g400 for real skill......oh wait, this lol forum not dota 2