Cait would run out of bullets..
And ashe arrows.

Ez would still be the best carry because he has infinite ammo.

While Draven's ult is traveling, he wouldn't be able to attack anything cause he just threw both of his axes.

Same with Olaf, he'd only have one until he picked the other one up.

cassiopeias ult wouldnt stun malphite

Upon entering the river, Xerath kills everything in said river

singed would need to work on his upper body strength

ok.

if league were more realistic, we'd just summon summoners who would then summon champions.

if league were more realistic, teemo wouldn't exist.

if league were more realistic, all the lady champions would throw themselves at me.