Originally Posted by Kunie
allright can someone explain the difference between glyphs and marks ect. also, which should i use for heroes like nunu and veigar?
Each type caters to one specific type of effect, and may have some from the other types but they tend to be weaker:
Marks (red): Attack. Specializes in Damage, Crit Damage, Crit Chance, Attack Speed, Armor Penetration
Glyphs (blue): Magic. Specializes in MP, MP Regen, Cooldown Reduction, AP, Magic Penetration
Seals (yellow): Defense. Specializes in HP, HP Regen, Armor, Magic Resist, Dodge Chance
Quintessence (purple): Power. Have the highest values for each type of rune, as well as some unique ones (Movement Speed, Experience gain, bonus Gold)
Also for Nunu, you're playing as a tank, so you probably want to stack stuff like HP, HP regen, Armor, and Magic resist.
For Veigar, you want to pick up 6% cooldown reduction (so with the 9% you get from a 9/0/21 spec you can have 40% with the golem buff, which is the max), then some combination of Magic Penetration (more effective than AP) and Mana Regen.