I've recently started playing Nasus as more of a DPS/Off-tank role. I've looked at a couple of guides and for the most part my item list goes in the way of Berserkers Greaves, Malady, Trinity Force, Banshee's Veil, and finally if I still have time or the money i get Phantom Dancer.
However, I don't really know how to set up my masteries or my rune page. I'm only lvl 11 so my masteries isn't that big of a deal but I do want to know for future reference. My rune page is what concerns me most. I have a crazy mix of armor pen., health, cd reduction, attack speed, and others. Any tips or advice would be helpful.