So, it seems like health runes are just a terrible value. For example, if you're the type champion that needs mana regen, this is the stat breakdown for HP runes vs mana regen runes:
Based off Meki Pendant and Ruby Crystal:
55 gold per MP5.
9 Clarity Seals Final Value = 825 Gold worth of MP5.
At level 3 9 Clarity Seals = 148 Gold worth of MP5.
2.37 Gold Per HP.
9 Fortitude Seals = 138 Gold worth of HP.
So at level 3, you're getting as much gold worth of stats out of the clarities.
Wouldn't it then be better, to get MP5 runes, and just start the game with a ruby crystal, as opposed to getting HP runes, and starting the game with a meki pendant?