Marks = MagicPen
Seals = Dodge
Glyphs = 0.57 MagicPen vs 0.99 AP vs 0.17 AP/level (3.06 at lvl 18)
Quents = 1.89 MagicPen vs 4.95 AP vs 0.43 AP/level (7.74 at lvl 18)

I do AP blitz, and I usually get boots of ionia and glacial shroud (35% CD reduc total, cap is 40% and offensive mastery gives 3% putting me a mere 2% from cap unless I really want to upgrade to frozen heart, heavily considering doing a glyph or two or a quent + glyph to cap me with just glacial shroud)

could definitely use some input, thanks ahead!

bump for great justice

I play Blitz more as an off tankish character.

Mpen reds,
mana regen/lvl yellows
magic resist/lvl blues
flat health quints

I start with a Meki since I enjoy spamming Q.
I then return when I have 1337 gold for Sheen.
I then get CDR Boots
Then I get Glacial Shroud and Banshees.

Get decent resists, and all of the bonus mana makes you pretty beast in regards to passive.

Sheen is enough damage for me. I play Blitz as a disrupt character. I have tried going Manamune before, and I really don't see the benefit. The extra mana was nice for passive shield, but I never find myself sitting around auto-attacking too much. It makes the E quite a bit nicer, but still not worth it over going for more off-tank items IMHO. Same with AP builds.

edit: 2% CDR is not worth subbing your other runes.

Armor Pen Reds
Crit chance Yellow
Magic Resist Blues
Armor Penetration Quintessences

21/9/0
Physical Attack masteries, Armor, Magic Res, and Regen based on mana pool for the extra HP5 early.

I play Blitz as a tanky dps champion.
Mana Saphire early, to build into Tear asap, which solves mana for the rest of the game. His power fist lets you last hit minions and does comparable damage to the grab at only 25 mana. Combined with lower cooldowns (down to 5 Seconds!) there's little reason to level the Grab early. The damage gain isn't wonderful, not compared to 2 pop ups, and its expensive mana wise.

You'll hit high base damage values very quickly. Pick up pieces of triforce and Banshee's Veil and you're doing a considerable amount of damage, are relatively tanky ( your manapool is ALWAYS near full), have a large amount of disrupts, and deal respectable burst and sustained damage.

id say no matter which way you play blitz either ot, ap, ad get some type of mana regen runs you will be glad you did. no more clarity or hurting for mana early game! and try ms quints ive seen alot of blitz do really good with them bc it endables them to get in range for pull alot faster.

I always play

health quints
magic pen reds
mana per level yellow
resist per level blue